S-STEM Scholar Kathy Serrano's Blog

Today I worked on assignment 11 of the protein bioinformatics project I was able to get information from the website and data provided ID: PIR_HUMAN DESCRIPTION: RecName: Full=Pirin; EC=1.13.11.24; AltName: Full=Probable quercetin 2,3-dioxygenase PIR; Short=Probable quercetinase; FUNCTION: Possible transcriptional coregulator. May contribute to the regulation of cellular processes via its interaction with BCL3. May be required for efficient terminal myeloid maturation of hematopoietic cells. May play a role in the regulation of cell migration. May promote apoptosis when overexpressed. Has quercetin 2,3-dioxygenase activity (in vitro). CATALYTIC ACTIVITY: Quercetin + O(2) = 2-(3,4- dihydroxybenzoyloxy)-4,6-dihydroxybenzoate + CO + H(+). COFACTOR: Binds 1 iron ion per subunit. ENZYME REGULATION: Inhibited by kojic acid, sodium diethyldithiocarbamate and 1,10-phenanthroline monohydrochloride. PATHWAY: Flavonoid metabolism; quercetin degradation. SUBUNIT: May interact wi...

Today I worked on assignment ten of the protein bioinformatics project I was able to get information from the website and data provided Description: Homo sapiens pirin (PIR), transcript variant 2, mRNA. (from RefSeq NM_001018109) RefSeq Summary (NM_001018109): This gene encodes a member of the cupin superfamily. The encoded protein is an Fe(II)-containing nuclear protein expressed in all tissues of the body and concentrated within dot-like subnuclear structures. Interactions with nuclear factor I/CCAAT box transcription factor as well as B cell lymphoma 3-encoded oncoprotein suggest the encoded protein may act as a transcriptional cofactor and be involved in the regulation of DNA transcription and replication. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000380420.10 Gencode Gene: ENSG00000087842.11 An ORegAnno record describes an experimentally proven and published regulatory region (promoter, en...

Today I worked on assignment nine of the protein bioinformatics project I was able to get information from the website and data provided Gene: PIR Description: Homo sapiens pirin (PIR), transcript variant 1, mRNA. (from RefSeq NM_003662) Ensembl gene ID: ENSG00000087842.6 GENCODE biotype: protein_coding Gene class: coding Highest median expression: 16.80 RPKM in Bladder Total median expression: 281.69 RPKM Score: 407 Genomic position: hg38 chrX:15384799-15493564 The NIH Genotype-Tissue Expression (GTEx) project was created to establish a sample and data resource for studies on the relationship between genetic variation and gene expression in multiple human tissues. This track shows median gene expression levels in 52 tissues and 2 cell lines, based on RNA-seq data from the GTEx final data release (V8, August 2019). This release is based on data from 17,382 tissue samples obtained from 948 adult post-mortem individuals. The scientific goal of the GTEx project required that the dono...