Today I worked on assignment 11 of the protein bioinformatics project I was able to get information from the website and data provided ID: PIR_HUMAN DESCRIPTION: RecName: Full=Pirin; EC=1.13.11.24; AltName: Full=Probable quercetin 2,3-dioxygenase PIR; Short=Probable quercetinase; FUNCTION: Possible transcriptional coregulator. May contribute to the regulation of cellular processes via its interaction with BCL3. May be required for efficient terminal myeloid maturation of hematopoietic cells. May play a role in the regulation of cell migration. May promote apoptosis when overexpressed. Has quercetin 2,3-dioxygenase activity (in vitro). CATALYTIC ACTIVITY: Quercetin + O(2) = 2-(3,4- dihydroxybenzoyloxy)-4,6-dihydroxybenzoate + CO + H(+). COFACTOR: Binds 1 iron ion per subunit. ENZYME REGULATION: Inhibited by kojic acid, sodium diethyldithiocarbamate and 1,10-phenanthroline monohydrochloride. PATHWAY: Flavonoid metabolism; quercetin degradation. SUBUNIT: May interact with NF1/CTF1. Interacts with BCL3. Identified in a complex comprised of PIR, BLC3, NFKB1 and target DNA. SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Predominantly localized in dot-like subnuclear structures. Cytoplasmic localization of PIR seems to positively correlate with melanoma progression. TISSUE SPECIFICITY: Highly expressed in a subset of melanomas. Detected at very low levels in most tissues (at protein level). Expressed in all tissues, with highest level of expression in heart and liver. INDUCTION: Up-regulated in CD34(+) cells upon myelomonocytic differentiation. Down-regulated in many acute myeloid leukemias. Up-regulated in primary bronchial epithelial cells exposed to cigarette smoke extract. POLYMORPHISM: Genetic variations in PIR might have a sex-specific influence on bone mineral density differences in some populations, as reported by PubMed:19766747. In a cohort of 4000 Chinese, a significant statistical association has been identified, in women but not in men, between the intronic SNP rs5935970 and lumbar spine bone mineral density, and between a haplotype composed of three SNPs with bone mineral density at other sites. This track was created by using Arian Smit's RepeatMasker program, which screens DNA sequences for interspersed repeats and low complexity DNA sequences. The program outputs a detailed annotation of the repeats that are present in the query sequence (represented by this track), as well as a modified version of the query sequence in which all the annotated repeats have been masked ten classes of repeats displayed in Repeat Masker -Short interspersed nuclear elements (SINE), which include ALUs -Long interspersed nuclear elements (LINE) -Long terminal repeat elements (LTR), which include retroposons -DNA repeat elements (DNA) -Simple repeats (micro-satellites) -Low complexity repeats -Satellite repeats -RNA repeats (including RNA, tRNA, rRNA, snRNA, scRNA, srpRNA) -Other repeats, which includes class RC (Rolling Circle) -Unknown The level of color shading in the graphical display reflects the amount of base mismatch, base deletion, and base insertion associated with a repeat element. The higher the combined number of these, the lighter the shading. Credits Thanks to Arian Smit, Robert Hubley and GIRI for providing the tools and repeat libraries used to generate this track.

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