Kathy serrano 

Protein: UniProt:O00625 PIR (1x) 

Today I worked on assignment five of the protein bioinformatics project I was able to get information from the website and data provided  

Pirin 

Pathway 

Flavonoid metabolism; quercetin degradation. 

Subcellular Location 

Nucleus. Cytoplasm. Note=Predominantly localized in dot-like subnuclear structures. Cytoplasmic localization of PIR seems to positively correlate with melanoma progression. 

Function 

Transcriptional coregulator of NF-kappa-B which facilitates binding of NF-kappa-B proteins to target kappa-B genes in a redox-state-dependent manner. May be required for efficient terminal myeloid maturation of hematopoietic cells. Has quercetin 2,3-dioxygenase activity (in vitro). 

GO Cellular Component 

cytoplasm; cytosol; nucleoplasm; (1 more) 

GO Molecular Function 

metal ion binding; quercetin 2,3-dioxygenase activity; transcription coregulator activity 

GO Biological Process 

digestion; monocyte differentiation; transcription by RNA polymerase II 

1- prostate adenocarcinoma  

Pirin down-regulates the EAF2/U19 protein and alleviates its growth inhibition in prostate cancer cells. 
Qiao Z et al. Prostate 74(2):113-120 
PMID: 24272884 

The effect of Pirin on EAF2/U19 inhibition of LNCaP growth was assayed by colony formation. RESULTS: Pirin co-immunoprecipitated with EAF2/U19 and the overexpressed Pirin decreased the expression level of EAF2/U19 protein in prostate cancer cell lines LNCaP and PC3. Furthermore, overexpression of EAF2/U19 suppressed LNCaP colony formation, and co-expression of Pirin significantly blocked the growth inhibition induced by EAF2/U19 overexpression. CONCLUSION: Pirin is a newly identified binding partner of EAF2/U19 capable of down-regulating EAF2/U19 protein and alleviating its inhibition of prostate cancer cell survival/proliferation. Pirin may play an important role involved in EAF2/U19 function as an androgen-responsive gene and tumor repressor. 

 

2- transitional cell carcinoma of the kidney 

Of every 100 cancers in the kidney, about 5 to 10 are transitional cell carcinomas (TCCs), also known as urothelial carcinomas. Transitional cell carcinomas don’t start in the kidney itself but in the lining of the renal pelvis (where the urine goes before it enters the ureter). This lining is made up of cells called transitional cells that look like the cells that line the ureters and bladder. Cancers that develop from these cells look like other urothelial carcinomas, such as bladder cancer, under the microscope. Like bladder cancer, these cancers are often linked to cigarette smoking and being exposed to certain cancer-causing chemicals in the workplace.  
 

3- acute lymphoblastic leukemia 

Gene Signature of High White Blood Cell Count in B-Precursor Acute Lymphoblastic Leukemia. 
Edwards H et al. PLoS One 11(8):e0161539 

Leukemia with an acute onset, characterized by the presence of lymphoblasts in the bone marrow and the peripheral blood. It includes acute B lymphoblastic leukemia and acute T lymphoblastic leukemia. 

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